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What Did You Take

What did you take?

A compound-by-compound risk reference for people who are going to take these things anyway — written by someone who is not selling them anything.

If you have been using something regularly and want to stop, start with am I dependent? — no quiz, no score, no email address.

The ratings

Six independent dimensions, never averaged into a single number, because a compound can be harmless in a single dose and cause permanent harm over a year, and one number would hide exactly that.

Compound Verdict DependenceAcute toxicityDocumented harmLong-term riskEvidence qualityProduct integrity
Creatine Well-characterised, low concern Dependence liability: 1 out of 5 Acute toxicity: 1 out of 5 Documented serious harm: 1 out of 5 Long-term / irreversible risk: 1 out of 5 Evidence quality: 5 out of 5 Product integrity risk: 2 out of 5
Kratom Works as advertised, real trade-offs Dependence liability: 4 out of 5 Acute toxicity: 3 out of 5 Documented serious harm: 4 out of 5 Long-term / irreversible risk: 2 out of 5 Evidence quality: 3 out of 5 Product integrity risk: 4 out of 5
LGD-4033 Works as advertised, real trade-offs Dependence liability: 1 out of 5 Acute toxicity: 2 out of 5 Documented serious harm: 3 out of 5 Long-term / irreversible risk: 3 out of 5 Evidence quality: 3 out of 5 Product integrity risk: 5 out of 5
MK-677 Works as advertised, real trade-offs Dependence liability: 1 out of 5 Acute toxicity: 2 out of 5 Documented serious harm: 2 out of 5 Long-term / irreversible risk: 3 out of 5 Evidence quality: 4 out of 5 Product integrity risk: 4 out of 5
Ostarine Works as advertised, real trade-offs Dependence liability: 1 out of 5 Acute toxicity: 2 out of 5 Documented serious harm: 3 out of 5 Long-term / irreversible risk: 3 out of 5 Evidence quality: 3 out of 5 Product integrity risk: 5 out of 5
BPC-157 Largely unknown Dependence liability: 1 out of 5 Acute toxicity: 2 out of 5 Documented serious harm: 1 out of 5 Long-term / irreversible risk: 3 out of 5 Evidence quality: 1 out of 5 Product integrity risk: 5 out of 5
Gray-market GLP-1s Serious risk Dependence liability: 1 out of 5 Acute toxicity: 4 out of 5 Documented serious harm: 3 out of 5 Long-term / irreversible risk: 2 out of 5 Evidence quality: 4 out of 5 Product integrity risk: 5 out of 5
Melanotan II Serious risk Dependence liability: 1 out of 5 Acute toxicity: 3 out of 5 Documented serious harm: 4 out of 5 Long-term / irreversible risk: 4 out of 5 Evidence quality: 1 out of 5 Product integrity risk: 5 out of 5
RAD-140 Serious risk Dependence liability: 1 out of 5 Acute toxicity: 2 out of 5 Documented serious harm: 4 out of 5 Long-term / irreversible risk: 4 out of 5 Evidence quality: 2 out of 5 Product integrity risk: 5 out of 5
Cardarine The evidence says don’t Dependence liability: 1 out of 5 Acute toxicity: 1 out of 5 Documented serious harm: 2 out of 5 Long-term / irreversible risk: 5 out of 5 Evidence quality: 2 out of 5 Product integrity risk: 4 out of 5
Phenibut The evidence says don’t Dependence liability: 5 out of 5 Acute toxicity: 4 out of 5 Documented serious harm: 4 out of 5 Long-term / irreversible risk: 2 out of 5 Evidence quality: 2 out of 5 Product integrity risk: 4 out of 5
Tianeptine The evidence says don’t Dependence liability: 5 out of 5 Acute toxicity: 4 out of 5 Documented serious harm: 5 out of 5 Long-term / irreversible risk: 2 out of 5 Evidence quality: 3 out of 5 Product integrity risk: 5 out of 5

Every score is 1–5 and higher always means more of that dimension. Evidence quality is the one that reads backwards: a high score there means well studied, not safe. How we rate, and how to challenge a rating.

Why you can believe this

No vendor money. No affiliate links. No advertising. No sponsorships. Nothing on this site is for sale.

Every ranking site in this space earns its money from the vendors it ranks. This one has no revenue, which is the only reason it is able to tell you not to buy something. If it ever takes vendor money, an affiliate commission or a sponsored placement, it becomes the thing it replaced and stops being worth reading. That is a promise you can check: the full editorial policy is published, and corrections are logged rather than quietly edited.

We also try to be right about the things you can already check. If you look up the compound you know about and we have exaggerated it, nothing else here is worth your time — which is why creatine is rated as low concern and says so plainly.